Muscle & recovery · Sleep · Aging & longevity
Sermorelin, simplified.
Also called GRF(1-29)
Human studiesThe first 29 building blocks of the body’s own growth-hormone signal. It was once an FDA-approved drug for children.
- Size
- 29 amino acids
- How it is taken
- Injection
- Status
- Compounded, formerly approved
What is it?
Sermorelin is the shortest piece of GHRH that still works. It tells the pituitary to release growth hormone in its natural pulses.
What studies show
- In peopleIt was approved in the 1990s to test and treat growth hormone deficiency in children.
- In peopleSmall studies in older adults showed higher growth hormone and IGF-1, with mixed effects on body composition.
What we don’t know yet
- Whether it slows aging or builds meaningful muscle in healthy adults.
Side effects and cautions
- Injection-site reactions, flushing and headache.
Is it legal?
The brand-name drug was withdrawn for business reasons, not safety. Today it is made by compounding pharmacies with a prescription.
Common questions
What is Sermorelin?
The first 29 building blocks of the body’s own growth-hormone signal. It was once an FDA-approved drug for children. Sermorelin is the shortest piece of GHRH that still works. It tells the pituitary to release growth hormone in its natural pulses.
What does the research say about Sermorelin?
It was approved in the 1990s to test and treat growth hormone deficiency in children. Small studies in older adults showed higher growth hormone and IGF-1, with mixed effects on body composition.
Is Sermorelin FDA approved?
The brand-name drug was withdrawn for business reasons, not safety. Today it is made by compounding pharmacies with a prescription.
What are the side effects of Sermorelin?
Injection-site reactions, flushing and headache.
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