Skin & hair
SNAP-8, simplified.
Also called Acetyl octapeptide-3
Human studiesA cosmetic peptide used in creams to soften expression lines. Sometimes called "topical Botox", though it is far weaker.
- Size
- 8 amino acids
- How it is taken
- Topical (skin creams and serums)
- Status
- Cosmetic ingredient
- Available sizes
- Vials: 10 mg
What is it?
SNAP-8 is designed to slightly interfere with the signal that tells facial muscles to contract, so expression lines may soften over time.
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What studies show
- In peopleManufacturer-run studies report modest reductions in wrinkle depth after about a month of use.
- In the labReduces the release of the muscle signal in lab dishes.
What we don’t know yet
- Results from independent studies.
- How much gets through the skin.
Side effects and cautions
- Generally well tolerated on skin.
Is it legal?
Sold as a cosmetic ingredient.
Dosage & schedule evidence
How to read published schedules
Third-party protocols are not established clinical dosing standards. Safe human dose, frequency, and duration may be unknown. Research findings may not translate to safe or effective personal use.
| Measurement | Meaning |
|---|---|
| 1 mg | 1,000 mcg (mass) |
| 100 U-100 units | 1 mL (volume, not dose) |
See third-party published protocols ↗ for research context. North Star does not validate these schedules.
Consult your doctor before considering any peptide for personal use. Educational only, not administration guidance.
Common questions
What is SNAP-8?
A cosmetic peptide used in creams to soften expression lines. Sometimes called "topical Botox", though it is far weaker. SNAP-8 is designed to slightly interfere with the signal that tells facial muscles to contract, so expression lines may soften over time.
What does the research say about SNAP-8?
Manufacturer-run studies report modest reductions in wrinkle depth after about a month of use. Reduces the release of the muscle signal in lab dishes.
Is SNAP-8 FDA approved?
Sold as a cosmetic ingredient.
What are the side effects of SNAP-8?
Generally well tolerated on skin.
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This page explains published research in plain language. It is not medical advice, a diagnosis, or a recommendation to take anything, and it does not give dosing. Most peptides here are not FDA-approved, and products sold online vary widely in purity. Rules around peptides are changing, so check the current status and talk with a licensed clinician before starting anything. Last reviewed 2026-10-19.