Libido
PT-141, simplified.
Also called Bremelanotide, Vyleesi
Approved RxA prescription peptide for low sexual desire that works on the brain, not blood flow.
- Size
- 7 amino acids (ring-shaped)
- How it is taken
- Injection as needed
- Status
- FDA-approved for one use
What is it?
PT-141 acts on melanocortin receptors in the brain, which are involved in desire. That is different from drugs like Viagra, which work on blood flow.
What studies show
- In peopleIn two large trials of premenopausal women with low desire, it modestly improved desire and reduced distress compared with placebo.
What we don’t know yet
- How well it works in men. Studies are small.
Side effects and cautions
- Nausea is common, affecting about 4 in 10 people in trials.
- It can briefly raise blood pressure.
- Repeated use can darken patches of skin.
Is it legal?
FDA-approved for premenopausal women with low sexual desire. Other uses are off-label.
Common questions
What is PT-141?
A prescription peptide for low sexual desire that works on the brain, not blood flow. PT-141 acts on melanocortin receptors in the brain, which are involved in desire. That is different from drugs like Viagra, which work on blood flow.
What does the research say about PT-141?
In two large trials of premenopausal women with low desire, it modestly improved desire and reduced distress compared with placebo.
Is PT-141 FDA approved?
FDA-approved for premenopausal women with low sexual desire. Other uses are off-label.
What are the side effects of PT-141?
Nausea is common, affecting about 4 in 10 people in trials. It can briefly raise blood pressure. Repeated use can darken patches of skin.
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This page explains published research in plain language. It is not medical advice, a diagnosis, or a recommendation to take anything, and it does not give dosing. Most peptides here are not FDA-approved, and products sold online vary widely in purity. Rules around peptides are changing, so check the current status and talk with a licensed clinician before starting anything. Last reviewed 2026-09-26.