Immune & gut · Healing & injury · Skin & hair
KPV, simplified.
Also called Alpha-MSH fragment
Early researchA three-building-block peptide studied for calming gut and skin inflammation.
- Size
- 3 amino acids
- How it is taken
- Oral, topical or injection
- Status
- Research compound, under FDA review
- Available sizes
- Vials: 5 mg, 10 mg · Capsules: 500 mcg
What is it?
KPV is the tail end of alpha-MSH, a natural hormone that helps control inflammation.
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What studies show
- In animalsIn mice with colitis, it reduced gut inflammation.
- In the labIn cell studies, it lowered inflammatory signals.
What we don’t know yet
- There are no real human trials yet.
Side effects and cautions
- Unknown in people.
Is it legal?
Not FDA-approved. Reviewed by an FDA advisory committee in July 2026 for wound healing and inflammation.
Dosage & schedule evidence
How to read published schedules
Third-party protocols are not established clinical dosing standards. Safe human dose, frequency, and duration may be unknown. Research findings may not translate to safe or effective personal use.
| Measurement | Meaning |
|---|---|
| 1 mg | 1,000 mcg (mass) |
| 100 U-100 units | 1 mL (volume, not dose) |
See third-party published protocols ↗ for research context. North Star does not validate these schedules.
Consult your doctor before considering any peptide for personal use. Educational only, not administration guidance.
Common questions
What is KPV?
A three-building-block peptide studied for calming gut and skin inflammation. KPV is the tail end of alpha-MSH, a natural hormone that helps control inflammation.
What does the research say about KPV?
In mice with colitis, it reduced gut inflammation. In cell studies, it lowered inflammatory signals.
Is KPV FDA approved?
Not FDA-approved. Reviewed by an FDA advisory committee in July 2026 for wound healing and inflammation.
What are the side effects of KPV?
Unknown in people.
Comes in these blends
- BPC-157 + KPV (500/500 mcg capsules): BPC-157 + KPV
- KLOW (50/10/10/10 mg vial): GHK-Cu + TB-500 + BPC-157 + KPV
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This page explains published research in plain language. It is not medical advice, a diagnosis, or a recommendation to take anything, and it does not give dosing. Most peptides here are not FDA-approved, and products sold online vary widely in purity. Rules around peptides are changing, so check the current status and talk with a licensed clinician before starting anything. Last reviewed 2026-10-19.