Focus & mood
Dihexa, simplified.
Also called PNB-0408
Early researchAn experimental compound that boosted memory and brain connections in rats. It has never been tested in people, and its mechanism raises safety questions.
- Size
- Modified 3-amino-acid peptide
- How it is taken
- Oral or injection
- Status
- Research compound
- Available sizes
- Vials: 10 mg
What is it?
Dihexa is built from a fragment of angiotensin. In the lab it boosts a growth signal called HGF, which helps brain cells form new connections.
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What studies show
- In animalsRats with memory problems performed better on maze tests.
- In the labIncreased the number of connections between brain cells in lab dishes.
What we don’t know yet
- Effects and safety in people. There are no human trials.
Side effects and cautions
- The HGF growth signal it boosts is also involved in cancer growth, which is a serious theoretical concern.
- No human safety data.
Is it legal?
Not FDA-approved for human use.
Dosage & schedule evidence
How to read published schedules
Third-party protocol charts are not established clinical dosing standards. The evidence for safe and effective human dose, frequency, and duration may be limited or absent.
| Measurement | Meaning |
|---|---|
| 1 mg | 1,000 mcg (mass) |
| 100 U-100 units | 1 mL (volume, not dose) |
Read third-party published protocols ↗ for context. North Star does not validate these schedules.
Consult your doctor before considering any peptide for personal use. Educational only, not administration guidance.
Common questions
What is Dihexa?
An experimental compound that boosted memory and brain connections in rats. It has never been tested in people, and its mechanism raises safety questions. Dihexa is built from a fragment of angiotensin. In the lab it boosts a growth signal called HGF, which helps brain cells form new connections.
What does the research say about Dihexa?
Rats with memory problems performed better on maze tests. Increased the number of connections between brain cells in lab dishes.
Is Dihexa FDA approved?
Not FDA-approved for human use.
What are the side effects of Dihexa?
The HGF growth signal it boosts is also involved in cancer growth, which is a serious theoretical concern. No human safety data.
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This page explains published research in plain language. It is not medical advice, a diagnosis, or a recommendation to take anything, and it does not give dosing. Most peptides here are not FDA-approved, and products sold online vary widely in purity. Rules around peptides are changing, so check the current status and talk with a licensed clinician before starting anything. Last reviewed 2026-10-19.